Zakład Radiobiologii i Ochrony Radiacyjnej

Publikacje

2025

1. Czylkowska, A.; Pitucha, M.; Raducka, A.; Fornal, E.; Kordialik-Bogacka, E.; Ścieszka, S.; Smoluch, M.; Burdan, F.; Jędrzejec, M.; Szymański, P. Thiosemicarbazone-Based Compounds: A Promising Scaffold for Developing Antibacterial, Antioxidant, and Anticancer Therapeutics. Molecules 2025, 30, 129. doi.org/10.3390/molecules30010129
2. Nakonieczna A., Abramowicz K., Kwiatek M., Zawadzka M., Banya I., Głowacka P., Skuza K., Lepionka T., Szymański P. Assessment of the prevalence of respiratory pathogens and the level of immunity to respiratory viruses in soldiers and civilian military employees in Poland Resp. Research 2025; 26, 62. doi.org/10.1186/s12931-025-03142-8
3. Zawadzka M., Lis A., Marszalkowska-Jakubik J., Szymanski P. Self-awareness of soldiers regarding risk factors for cardiovascular diseases. International J. Occup. Med. Enviro. Health 2025, 38, 1. doi.org/10.13075/ijomeh.1896.02513
4. Zawadzka M, Marszałkowska-Jakubik J., Ejchman-Pac E., Pająk-Tarnacka B., Szymański P. Assessing Cardiovascular Risk Among Polish Soldiers: Insights Using the POL-SCORE Tool J. Clin. Med. 2025, 14, 2130. doi.org/10.3390/jcm14062130
5. Kręcisz P., Stefańska K., Studziński J., Czylkowska A., Pitucha M., Szymański P. Radiocopper in Radiopharmacy and Medical Use: Current Status and Perspective. J. Med. Chem. 2025, 68, 2356−2376 DOI: 10.1021/acs.jmedchem.4c02885
6. Czarnecka K, Jędrzejec M, Kukiełczyńska A, Owczarek J, Olejnik Ł, Szymański P. Selected Medicines That Can Cause Cardiac Arrest with Asystole. Curr. Iss. Mol. Biol. 2025, 47, 5, 299. doi.org/10.3390/cimb47050299

2024

1. Ejchman-Pac, E.; Rzepka, M.; Gierlach, M.; Szymański, P.; Zawadzka, M. Evaluation of Knowledge and Self-Awareness of Polish Soldiers Regarding Exposure to Chemical and Physical Factors in Their Place of Service/Work. Healthcare 2024, 12, 450. doi.org/10.3390/healthcare12040450
2. Czylkowska A., Pitucha M., Lanka S., Raducka A., Rogalewicz B., Szczesio M., Świątkowski M., Żarczyński A., Klepacz-Smółka A., Szczytko J., Camargo B., Drabińska A., Szymański P., Triazole-based Mn(II), Fe(II), Ni(II), Cu(II) and Zn(II) complexes as potential anticancer agents – Physicochemical properties, in silico predictions and in vitro activity. Polyhedron. Volume 261, 2024, 261, 117106. doi.org/10.1016/j.poly.2024.117106
3. Zawadzka, M.; Lis, A.; Marszałkowska-Jakubik, J.; Szymański, P. Evaluation of Soldiers’ Knowledge and Sense of Threats Regarding Exposure to Biological Risk Factors at the Place of Service. Healthcare 2024, 12, 1777. doi.org/10.3390/healthcare12171777
4. Maciejewska K., Czarnecka K., Szymański P. Bioavailability enhancement of coenzyme Q10: An update of novel approaches Archiv Pharm. 2024, 357, 8, e2300676 DOI:10.1002/ardp.202300676
5. Zuzanna Dominiak, Kamila Czarnecka, Agnieszka Czylkowska, Pawel Szymanski Nanoparticles-Key to the Future Pharmacotherapy of the Cardiovascular Diseases J. Biomed. Nanotechnol. 2024 20, 1679–1691. doi:10.1166/jbn.2024.3929

2023

1. Czarnecka K., Girek M., Kręcisz P., Skibiński R., Łątka K., Jończyk J., Bajda M., Szymczyk P., Galita G., Kabziński J., Majsterek I., Espargaró A., Sabate R., Szymański P. New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s disease, J. Enz. Inh. Med. Chem. 2023, 38, 2158822, 1-13. DOI:10.1080/14756366.2022.2158822
2. Cebulska, E., Malik, K., Czarnecka, K., Szymański, P. Additional degradants in the impurity profile of atropine low-dose ophthalmic solution Acta Pol Pharma - Drug Research 2023, 80, 4, 541-550 DOI: 10.32383/appdr/169782
3. Szałek, E., Musiał, B., Czarnecka, K., Szymański, P. Simultaneously determination of fine particle dose of vilanterol and fluticasone furoate for dry powder inhaler (dpi) by utilizing gradient elution in chromatography system Acta Pol Pharma - Drug Research 2023, 80, 4, 551-565. DOI: 10.32383/appdr/170317

2022

1. Szymczyk P, Szymańska G., Majewska M., Weremczuk-Jeżyna I, Kołodziejczyk M., Czarnecka K., Szymański P., Kochan E. Homology modeling and docking studies of strictosidine β-D-glucosidase from Madagascar periwinkle (Catharanthus roseus Bunge) Int. J. Bioinf. Research and Applications 2022, 18(1/2), 1. DOI: 10.1504/ijbra.2022.10033607
2. Maciejewska, K.; Czarnecka, K.; Kręcisz, P.; Niedziałek, D.; Wieczorek, G.; Skibiński, R.; Szymański, P. Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 5876. doi.org/10.3390/ijms23115876
3. Czylkowska, A.; Rogalewicz, B.; Szczesio, M.; Raducka, A.; Gobis, K.; Szymański, P.; Czarnecka, K.; Camargo, B.C.; Szczytko, J.; Babich, A.; Dubkov, S.; Lazarenko, P. Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles. Int. J. Mol. Sci. 2022, 23, 2980. doi.org/10.3390/ijms23062980
4. Staśkiewicz M., Nowicki M., Majewska K., Nadajczyk J., Rogut A., Czarnecka K, Szymański P Evaluation of the potential impact of cherry flavour on the stability of montelukast tablets. Acta Pol. Pharma. – Drug Research 2022, 23 DOI:10.32383/appdr/151572
5. Koźmiński, P.; Niedziałek, D.; Wieczorek, G.; Halik, P.K.; Czarnecka, K.; Rogut, A.; Cheda, Ł.; Rogulski, Z.; Szymański, P.; Gniazdowska, E. New Imaging Modality of COVID-19 Pneumonia Developed on the Basis of Alzheimer’s Disease Research. Int. J. Mol. Sci. 2022, 23, 8405. https://doi.org/10.3390/ijms23158405
6. Kosińska, A.; Virieux, D.; Pirat, J.-L.; Czarnecka, K.; Girek, M.; Szymański, P.; Wojtulewski, S.; Vasudevan, S.; Chworos, A.; Rudolf, B. Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru). Int. J. Mol. Sci. 2022, 23, 8091. doi.org/10.3390/ijms23158091
7. Rogalewicz, B.; Climova, A.; Pivovarova, E.; Sukiennik, J.; Czarnecka, K.; Szymański, P.; Szczesio, M.; Gas, K.; Sawicki, M.; Pitucha, M.; Czylkowska, A. Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes. Molecules 2022, 27, 2703. doi.org/10.3390/molecules27092703
8. Czylkowska, A.; Lanka, S.; Szczesio, M.; Czarnecka, K.; Szymański, P.; Pitucha, M.; Drabińska, A.; Camargo, B.C.; Szczytko, J. New Derivatives of 5-((1-Methyl-Pyrrol-2-yl) Methyl)-4-(Naphthalen-1-yl)-1,2,4-Triazoline-3-Thione and Its Coordination Compounds with Anticancer Activity. Int. J. Mol. Sci. 2022, 23, 9162. doi.org/10.3390/ijms23169162
9. Raducka A, Świątkowski M, Gobis K, Szymański P, Czylkowska A. In Silico ADME and Toxicity Prediction of Benzimidazole Derivatives and Its Cobalt Coordination Compounds. Synthesis, Characterization and Crystal Structure. Molecules. 2022; 27(22), 8011. doi.org/10.3390/molecules27228011
10. Krzyzowska, M.; Janicka, M.; Tomaszewska, E.; Ranoszek-Soliwoda, K.; Celichowski, G.; Grobelny, J.; Szymanski, P. Lactoferrin-Conjugated Nanoparticles as New Antivirals. Pharmaceutics 2022, 14, 1862. doi.org/10.3390/pharmaceutics14091862
11. Zawadzka M, Nowik M, Ejchman-Pac E, Szymański P, Curyło M, Marszałkowska-Jakubik J. Carcinogenic Factors in the Military Environment: Threats and Challenges to the Health of Soldiers and Military Personnel. Pol J Aviat Med Bioeng Psychol 2022; 28(1): 22-30. DOI: 10.13174/pjambp.28.03.2025.02

2021

1. Raducka, A.; Czylkowska, A.; Gobis, K.; Czarnecka, K.; Szymański, P.; Świątkowski, M. Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer. Materials 2021, 14, 2958. https://doi.org/10.3390/ma14112958
2. Nowosielska, E.M.; Cheda, A.; Pociegiel, M.; Cheda, L.; Szymański, P.; Wiedlocha, A. Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice. Int. J. Mol. Sci. 2021, 22, 6309. https://doi.org/10.3390/ijms22126309
3. Czylkowska, A.; Szczesio, M.; Raducka, A.; Rogalewicz, B.; Kręcisz, P.; Czarnecka, K.; Szymański, P.; Pitucha, M.; Pawlak, T. Cytotoxic Activity against A549 Human Lung Cancer Cells and ADMET Analysis of New Pyrazole Derivatives. Int. J. Mol. Sci. 2021, 22, 6692. https://doi.org/10.3390/ijms22136692
4. Kręcisz P., Czarnecka K., Szymański P. Thin layer chromatography gradient optimization strategy for wet load adsorption flash chromatography J. Chrom. Sci 2021 , 60, 5, 472–477. DOI:10.1093/chromsci/bmab097
5. Czarnecka K., Chuchmacz J., Wójtowicz P., Szymański P. Memantine in neurological disorders – schizophrenia and depression J. Mol. Med. 2021, 99, 327–334. DOI: 10.1007/s00109-020-01982-z
6. Kręcisz P, Czarnecka K, Królicki L, Mikiciuk-Olasik E., Szymański P. Radiolabeled Peptides and Antibodies in Medicine Bioconj. Chem. 2021, 32, 25−42. doi.org/10.1021/acs.bioconjchem.0c00617
7. Dominiak Z., Huras H., Kręcisz P., Krzeszowski W., Szymański P, Czarnecka K. Promising results in development of male contraception Bioorg. Med. Chem. Lett. 2021, 41, 128005. doi.org/10.1016/j.bmcl.2021.128005
8. Maciejewska K, Czarnecka K., Szymański P A review of the mechanisms underlying selected comorbidities in Alzheimer's Disease, Pharmacol. Rep. 2021, 73(6):1565-1581. DOI: 10.1007/s43440-021-00293-5
9. Czarnecka, K.; Pilarz, A.; Rogut, A.; Maj, P.; Szymańska, J.; Olejnik, Ł.; Szymański, P. Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products. Nutrients 2021, 13, 1957. doi.org/10.3390/nu13061957

2020

1. Abend M. , Stricklin D., Flaig N., Badie C., Drouet M., Foster C., Janiak M.K., Kuipers T., Lista F., Nowosielska E.M., Riccobono D., de Sanctis S., Franchini V., Tichy A., Port M. Bringing Radiation Exposures and Associated Health Risks Into Perspective—Development of an APP. Health Phys 119(1): 59-63, doi: 10.1097/HP.0000000000001246, 2020 (IF 0,853).

2019

1. Dobrzyński L, Fornalski KW, Reszczyńska J, Janiak MK. Modeling Cell Reactions to Ionizing Radiation: From a Lesion to a Cancer. Dose Response 17(2):1559325819838434, doi: 10.1177/1559325819838434, 2019 (IF 2.451).
2. Zakrzewski A, Kruszewski J, Chciałowski A, Kłos K, Rzeszotarska A, Korsak J, Nowosielska EM, Cheda A, Wrembel-Wargocka J, Janiak MK. How fast does wasp venom immunotherapy affect a regulatory T cell subpopulation (CD4+CD25+Foxp3+) and the synthesis of interleukins 10, 21 and transforming growth factor β1? Adv Dermatol Allergol XXXVI(1): 82-85, 2019 (IF 1.757).
3. Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM. Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. Cells 8(6), doi:10.3390/cells8060518, 2019 (IF 5,656).

2018

1. Nowosielska EM., Cheda A., Zdanowski R., Lewicki S., Scott BR., Janiak MK. Effect of internal contamination with tritiated water on the neoplastic colonies in the lungs, innate anti-tumour reactions, cytokine profile, and haematopoietic system in radioresistant and radiosensitive mice. Radiation Environ Biophys doi: 10-1007/s00411-018-0739-4, 2018 (IF 2,398)
2. Mortazavi SMJ., Bevelacqua JJ., Fornalski KW., Pennigton CW., Welsh J., Janiak MK., Dobrzynski L., Doss M. Letter to the editor (August 24, 2017) concerning the paper “Occupational exposure to radon for underground tourist routes in Poland: Doses to lung and the risk of developing lung cancer.” Int J Occup Med Env, doi: 10.13075/ijomeh.1896.01257, 2018 (IF 0,947).
3. Praca zbiorowa pod redakcją: Hérodin F. Biological Effects of Ionising Radiation and Countermeasures. Final Report of Research Task Group HFM-222, STO/NATO, ISBN 978-92-837-2055-3, 2018.

2017

1. Janiak M.K., Wincenciak M., Cheda A., Nowosielska E.M., Calabrese E.J. Cancer immunotherapy: How low-level ionizing radiation can play a key role. Cancer Immunol Immunother 66:819-832, 2017 (IF 4,711).
2. Dobrzyński L., Janiak M.K., Strupczewski A., Waligórski M. O konieczności zmiany paradygmatu ochrony radiologicznej – Komentarz SARI – Stowarzyszenia Uczonych dla Rzetelnej Informacji o Promieniowaniu. Postępy Techniki Jądrowej 60(3):2-11, 2017.

2016

1. Zakrzewski A., Kruszewski J., Chciałowski A., Kłos K., Rzeszotarska A., Korsak J., Nowosielska EM., Cheda A., Wrembel-Wargocka J., Janiak MK. Jak szybko immunoterapia jadem osy wpływa na syntezę cytokin IL-10, IL-21, TGF-beta1? Lekarz Wojskowy 94:139-142, 2016.
2. Praca pod redakcją: Herodin F., Janiak M.K. Ionizing Radiation Bioeffects and Countermeasures. STO-TR-HFM-222, ISBN 978-92-837-2055-3, 2016.
   Rozdział:
   Janiak M.K., Nowosielska E.M., Cheda A., Wincenciak M., Wrembel-Wargocka J. Protection and treatment with nicotinic acid and its derivatives (a mouse model). str.31-38.
3. Janiak M.K., Nowosielska EM., Cheda A., Wincenciak M., Wrembel-Wargocka J. Evaluation of the effect of low doses of low-LET radiation on the innate antitumor reactions in radioresistant and radiosensitive mice. str. 117-130.
4. Janiak M.K., Nowosielska E.M., Cheda A., Wincenciak M., Wrembel-Wargocka J. Effect of internal contamination with tritiated water on the innate antitumor and inflammatory reactions in radioresistant and radiosensitive mice – A preliminary study. str. 131-138.

2015

1. 1. Praca pod redakcją: Zmyślony M, Nowosielska EM. Ochrona przed promieniowaniem jonizującym i niejonizującym. Nowe uregulowania prawne, źródła, problemy pomiarowe. WAT, ISBN 978-83-7938-082-4, 2015.
   Rozdział:
   Nowosielska E.M., Cheda A., Wrembel-Wargocka J., Wincenciak M., Janiak M.K. Hormeza radiacyjna. str. 54-74.

2014

1. Janiak M.K. Epidemiological evidence of childhood leukaemia around nuclear power plants. Dose-Response 12:349-364, 2014 (IF 1,217).
2. Socol Y., Cuttler J.M., Dobrzyński L., Doss M., Feinendegen L.E., Fornalski K.W., Janiak M.K., Miller M.L., Rithidech K.N., Sanders C.L., Scott B.R., Ulsh B., Vaiserman A., Welsh J. Comment on “NAIRAS aircraft radiation model development, dose climatology, and initial validation” by Mertens et al. Space Weather 12:120–121, 2014 (IF 2,149).

2013

1. Socol Y., Dobrzyński L., Doss M., Feinendegen LE., Janiak MK., Miller ML., Sanders CL., Scott BR., Ulsh B., Vaiserman A. Commentary: Ethical issues of current health-protection policies on low-dose ionizing radiation. Dose Response 12:342-348, 2013 (IF 1,234).
2. Praca pod redakcją: Skopińska-Różewska E, Siwicki AK, Zdanowski R. Biologia medyczna. Wybrane zagadnienia. EDYCJA s.c., ISBN 978-83-88545-83-2, 2013.
   Rozdziały:
   Cheda A., Nowosielska EM., Wrembel-Wargocka J., Wincenciak M., Janiak MK. Radioprotektory – związki zmniejszające skutki negatywnego działania promieniowania jonizującego na organizmy żywe. str. 29-45.
   Nowosielska E.M., Cheda A., Wincenciak M., Wrembel-Wargocka J., Janiak M.K. Skutki działania małych dawek promieniowania jonizującego na organizmy żywe. str. 147-171.